You will progress through an Expedition by deciding which paths to take. Miracles and Boons can be earned, and weapons can be discovered and upgraded along the way.
Miracles, Boons and weapons will not persist from one Expedition to the next; however, some of your Pilgrim’s Coins will.
Do I Have To Complete An Expedition to Save My Progress?
Yes. You must complete one full Expedition in a single play session in order to progress. You can return later to do another Expedition.